TY - JOUR AU - Carvalho, Rita do Espírito Santo PY - 2015 TI - How do I diagnose Pagetoid Bowen Disease JF - Diagnostic Pathology; 2015 DO - 10.17629/www.diagnosticpathology.eu-2015-1:88 KW - Paget Disease; elastotic degeneration; Skin; p63 N2 - Bowen disease is a variant of squamous carcinoma in situ, which sometimes presents with a pagetoid growth pattern with cytologically atypical clear cells. In that case, the differencial diagnosis includes Paget disease and melanoma in situ, as well as less common entities. Here we describe a case where histological differenciation is difficult and immunohistochemical studies are necessary to make a diagnosis. Here we also highlight the heterogeneity of CK7 expression and the apparent specific expression of p63 in Pagetoid Bowen Disease. UR - http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/88