Cryptosporidiosis in an Immunocompetent Individual An unusual case with brief review of the literature

  • Bo Jin Wayne State University Sinai Grace Hospital/ Detroit Medical Center
  • Anveil Yashpal Medical University of the Americas
  • Nisha Deol Medical University of the Americas
  • Ahmed AbuRashed Medical University of the Americas
  • Husain Saleh

Abstract

Cryptosporidiosis infection involves most commonly the small intestine but can occur in any part of the gastrointestinal (GI) tract. Typical infection by this parasitic organism occurs in immunocompromised individuals. However, rare cryptosporidiosis in immunocompetent individuals has been reported.  Herein, we describe a case of cryptosporidiosis in an 85-year old woman who has hypertensive heart disease and diabetes, but is otherwise immunocompetent. This patient had protracted chronic diarrhea, however, medical workup failed to identify the etiology of this diarrhea.

Awareness of the possibility that cryptosporidiosis can involve immunocompetent individuals should be kept in mind among healthcare professionals to avoid misdiagnosis or lengthy delay in identifying the cause of the diarrhea or other GI illness. In particular, obtaining biopsy of the small or large intestines by the examining gastroenterologists in spite of normal endoscopy is very important to establish the diagnosis.

 

 

 

Downloads

Download data is not yet available.

Author Biographies

Bo Jin, Wayne State University Sinai Grace Hospital/ Detroit Medical Center

Assistant Professor of Pathology

Wayne State University

Department of Pathology

Sinai Grace Hospital/ Detroit Medical Center

 

Anveil Yashpal, Medical University of the Americas
Medical University of the Americas
Nisha Deol, Medical University of the Americas
Medical University of the Americas
Ahmed AbuRashed, Medical University of the Americas
Medical University of the Americas

References

1. Chen XM, Keithly JS, Paya CV, LaRusso NF: Cryptosporidiosis. N Engl J Med 2002, 346:1723.
2. Yoder JS, Wallace RM, Collier SA, et al: Cryptosporidiosis surveillance--United States, 2009-2010. MMWR Surveill Summ 2012, 61:1.
3. Mor SM, Tzipori S. Cryptosporidiosis in children in Sub-Saharan Africa: a lingering challenge. Clin Infect Dis 2008, 47:915.
4. Framm SR, Soave R. Agents of diarrhea. Med Clin North Am 1997, 81:427.
5. Yoder JS, Beach MJ, Centers for Disease Control and Prevention (CDC). Cryptosporidiosis surveillance--United States, 2003-2005. MMWR Surveill Summ 2007, 56:1.
6. Heyworth MF. Parasitic diseases in immunocompromised hosts. Cryptosporidiosis, isosporiasis, and strongyloidiasis. Gastroenterol Clin North Am 1996, 25:691.
7. Genta RM, Chappell CL, White AC Jr, et al. Duodenal morphology and intensity of infection in AIDS-related intestinal cryptosporidiosis. Gastroenterology 1993, 105:1769.
8. Jokipii L, Jokipii AM. Timing of symptoms and oocyst excretion in human cryptosporidiosis. N Engl J Med 1986, 315:1643.
9. Scallan E, Hoekstra RM, Angulo FJ, et al. Foodborne illness acquired in the United States—major pathogens. Emerg Infect Dis 2011, 17:7–15.
10. Santin M, Trout JM, Xiao L, et al. Prevalence and age-related variation of Cryptosporidium species and genotypes in dairy calves. Vet Parasitol 2004, 122:103–17.
11. Xiao L, Zhou L, Santin M, Yang W, Fayer R. Distribution of Cryptosporidium parvum subtypes in calves in eastern United States. Parasitol Res 2007, 100:701–
12. D'Antonio RG, Winn RE, Taylor JP, et al. A waterborne outbreak of cryptosporidiosis in normal hosts. Ann Intern Med 1985, 103:886–8.
13. Current William, Reese Norman, Ernst John, Bailey Wilford, et al. Human Cryptosporidiosis in Immunocompetent and Immunodeficient Persons. N Engl J Med 1983, 308:12527
14. Wolfson John, Richter James, Waldron Mary Ann, et al. Cryptosporidiosis in Immunocompetent Patients. N Engl J Med 1985, 312:1278-82
Published
2015-05-26
How to Cite
JIN, Bo et al. Cryptosporidiosis in an Immunocompetent Individual An unusual case with brief review of the literature. Diagnostic Pathology, [S.l.], may 2015. ISSN 2364-4893. Available at: <http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/10>. Date accessed: 26 nov. 2020. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2015-1:10.
Issue
Section
Case Report

Keywords

cryptosporidiosis, immunocompetent, chronic diarrhea