Low Grade Well-circumscribed Well Differentiated Liposarcoma Developed in Fibroadenoma with Stromal adipose differentiation of the Breast; A Case Report
Fibroadenomas are the most common breast tumor in adolescents and young women.They comprise Â 20% of benign breast masses and 12% of all breast masses in postmenopausal women. Smooth muscle metaplasia and adipose differentiation are uncommon forms of stromal differentiation encountered in a minority of fibroadenomas. Liposarcoma can arise from pre-existing benign lesions like phylloides tumour or from lipoid tissue in the breast. In this article we present a case of 38 year-old female who presented with a right breast mass which was clinically diagnosed as a case of fibroadenoma, but histologically showed a low grade well-circumscribed liposarcoma discovered in a pericanalicular type of fibroadenoma with stromal adipose differentiation. According to our knowledge, this the first case of a well-circumscribed liposarcoma arises in fibroadenoma of the breast.
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2. Hunter TB, Roberts CC, Hunt KR, Fajardo LL: Occurrence of fibroadenomas in postmenopausal women referred for breast biopsy. J Am Geriatr Soc 1996,44:61â€“64.
3. Guray M, Sahin AA: Benign breast diseases:classification, diagnosis,and management. Oncologist 2006, 11(5):435-449.
4. Buzanowski-Konakry K, Harrison Jr EG, Payne WS: Lobular carcinoma arising in fibroadenoma of the breast. Cancer 1975, 35:450-456.
5. Goldman RC, Friedman NB: Carcinoma of the breast arising in fibroadenomas with emphasis on lobular carcinoma. A clinicopathologic study. Cancer 1969, 23:544-550.
6. McDivitt RW, Stewart FW, Farrow JH: Breast carcinoma arising in solitary fibroadenomas. Surg Gynecol Obstet 1967, 125:572-576.
7. Goodman ZD, Taxy JB: Fibroadenomas of the breast with prominent smooth muscle. Am J Surg Pathol 1981, 5:99-101.
8. Magro G, Bisceglia M, Pasquinelli G: Benign spindle cell tumor of the breast with adipocytic component. Ann Diagn Pathol 1998Oct, 2(5):306-11.
9. Powell CM, Rosen PP. Adipose differentiation in cystosarcoma phyllodes: a study of 14 cases. Am J Surg Pathol 1994,18:720â€“727.
10. Rosen P & Oberman H: [Tumors of the mammary gland],Seated in Armed Forces Institute of Pathology. Washington, DC; 1993:107â€“12.
11. Norris HJ & Taylor HB. Relationship of histologic features to behavior of cystosarcoma phyllodes: analysis of ninety-four cases. Cancer 1967, 20:2090â€“99.
12. Rosen PP, Romain K, Liberman L. Mammary cystosarcoma with mature adipose stromal differentiation (lipophyllodes tumor) arising in a lipomatous hamartoma. Arch Pathol Lab Med 1994 Jan, 118(1):91-4.
13. Isolato PA, George RL, Walker R, Sengupta SK. Malignant phyllodes tumor with liposarcomatous differentiation. Arch Pathol Lab Med 2005 Mar, 129(3):421-2.
14. Lee JW, Nadelman CM, Hirschowitz SL, Debruhl ND, BassettLW. Malignant Phyllodes tumor of a genotypic male phenotypic female with liposarcomatous differentiation. Breast J 2007 May-Jun, 13(3):312-3.
15. Satou T, Matsunami N, Fujiki C, Tanaka K, Hayashi Y, Hashimoto S. Malignant phyllodes tumor with liposarcomatous components: a case report with cytological presentation. Diagn Cytopathol. 2000 Jun;22 (6):364-9.
16. Mazaki T, Tanak T, Suenaga Y, Tomioka K, Takayama T. Liposarcoma of the breast: a case report and review of the literature. Int Surg 2002; 87:164-70.
17. Austin RM, Dupree WB. Liposarcoma of the breast: a clinicopathologic study of 20 cases. Hum Pathol. 1986;17:906â€“913.
18. Nandipati KC, Nerkar H, Satterfield J, Velagapudi M, Ruder U, Sung KJ. Pleomorphic Liposarcoma of the Breast Mimicking Breast Abscess in a 19-Year-Old Postpartum Female: a Case Report and Review of the Literature . The Breast Journal Volume 16 Number 5, 2010 537â€“540
19. Farid Moinfar. Phylloides Tumor. In Essentials of diagnostic breast pathology . Springer-Verlag Berlin Heidelberg; 2007. pp322-323.
20. Rosen PP.[Sarcoma].Seated in Rosenâ€™s Breast Pathology. 3rd Edition. Philadelphia,Pa Lippincott Williams & Wilkins; 2009: 906-908.
21. Moffat CJ, Pinder SE, Dixon AR, Elston CW, Blamey RW, Ellis IO . Phyllodes tumours of the breast: a clinicopathological review of thirty-two cases. Histopathology 1995 Sep;27(3):205-18.
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