How do I diagnose Primary neuroendocrine tumor of the breast

  • László Fónyad 1st Department of Pathology and Experimental Cancer Research, Semmelweis University
  • László Piros
  • Gabriella Arató

Abstract

Primary neuroendocrine tumor of the breast is a rare condition. Although 20-30% of primary breast cancers show neuroendocrine differentiation to some degree, according to the WHO classification, at least 50% of the tumor cells have to be positive with at least one neuroendocrine immunohistochemical marker to establish a diagnosis of neuroendocrine tumor of the breast while clinically excluding other primary sites and a metastatic nature. Due to the low prevalence of this disease our understanding of its development, prognosis and effective therapy is limited. Up to date there are 125 cases reported in the English and non-English literature, now including our own case as well. We report a case of a 75 years old female. The patient presented with a 2 cm large mobile nodule in the upper outer quadrant of the left breast. Lumpectomy was performed based on fine needle aspiration cytology with a positive result showing malignant proliferation. Examination of the surgical specimens revealed neuroendocrine differentiation in approximately 90% of the tumor cells. Immunohistochemical studies and additional imaging studies revealed no other primary.

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References

1. Adams R.W. et al, Neuroendocrine breast tumours: Breast cancer or neuroendocrine cancer presenting in the breast? , The Breast 23 (2014) 120e127

2. Ghanem S. et al, Primary neuroendocrine carcinoma of the breast: A rare and distinct entity, Journal of Cancer Research and Experimental Oncology Vol. 3(5): 50-54.

3. Adegbola T. et al, Small cell neuroendocrine carcinoma of the breast: a report of three cases and review of the literature, J Clin Pathol 2005;58:775-778.

4. Angarita et al. , Locally-advanced primary neuroendocrine carcinoma of the breast: case report and review of the literature, World Journal of Surgical Oncology 2013, 11:128
Published
2016-02-04
How to Cite
FÓNYAD, László; PIROS, László; ARATÓ, Gabriella. How do I diagnose Primary neuroendocrine tumor of the breast. Diagnostic Pathology, [S.l.], v. 2, n. 1, feb. 2016. ISSN 2364-4893. Available at: <http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/101>. Date accessed: 26 nov. 2020. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2016-2:101.
Section
How do I diagnose

Keywords

Keyword - Diagnosis: Primary neuroendocrine tumor of the breast Keyword - differential diagnosis: Metastatic neuroendocrine tumor Keyword - side findings: Keyword - organ: breast Keyword - methods: Immunohystochemistry