Contribution of Measurement to morphologic Diagnostics

  • Klaus Kayser Charite Berlin
  • Stephan Borkenfeld
  • Rita Carvalho
  • Gian Kayser


Interactive contribution:


Pathologists' diagnostics are based upon morphology, which means to distinguish between structure and function. Morphology is the evaluation of biological structures. These are ordered clusters of material (genes, nuclei, cells, organs, etc.) that remain constant during the period of detection and observation. The observation time is an important factor that defines biological structures and diagnostics too. The implementation of measurement - based diagnostic algorithms improves the accuracy and serves for quality assurance in tissue - based diagnosis.


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1. Kayser, K., et al., The concept of entropy in histopathological diagnosis and targeted therapy. Diagnostic Pathology 2015, 1:97.

2. Sharma, H., et al., A review of graph-based methods for image analysis in digital histopathology. Diagnostic Pathology 2015, 1:61.

3. Kayser, K. and H.J. Gabius, The application of thermodynamic principles to histochemical and morphometric tissue research: principles and practical outline with focus on the glycosciences. Cell Tissue Res, 1999. 296(3): p. 443-55.

4. Sousa V., et al., EGFR and KRAS mutation coexistence in lung adenocarcinomas. Diagnostic Pathology 2015, 1:13.
How to Cite
KAYSER, Klaus et al. Contribution of Measurement to morphologic Diagnostics. Diagnostic Pathology, [S.l.], v. 2, n. 1, mar. 2016. ISSN 2364-4893. Available at: <>. Date accessed: 13 july 2024. doi:
Interactive publication


interactive publication ;Morphological diagnostics; epistemological; methodological; individual; communicative; economical and ethical limits

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