How do I diagnose Extramedullary Hematopoiesis

  • Rita Carvalho
  • Manuela Mafra

Abstract

Extramedullary hematopoiesis occurs in bone marrow disorders and is most commonly seen in thalassemia and myelofibrosis. We present a case of a 58 year-old male, with a history of thalassemia, which presented with a para-vertebral mass composed of hematopoietic tissue. When considering the differential diagnosis, a primary concern was an extramedullary proliferation of neoplastic hematopoietic elements, like extramedullary myeloid sarcoma. Neoplastic extramedullary proliferations can consist of triline age marrow elements and closely mimic the appearance of benign extramedullary hematopoiesis. The morphologic appearance may be a diagnostic clue, but cannot be completely relied upon.

Downloads

Download data is not yet available.

Author Biography

Rita Carvalho

Pathology Resident - Central Lisbon Hospital Center

Lisbon - Portugal

References

1. An J., et al., Intrathoracic extramedullary hematopoiesis presenting as tumor simulating lesions of the mediastinum in α thalassemia: A case report, Oncology Letters 2015, 10: 1993-1996.

2. O’Malley D.P., Benign extramedullary myeloid proliferations, Modern Pathology 2007, 20:405-415.

3. Qiu D., et al, Extramedullary hematopoiesis on 18F-FDG PET/CT in a patient with thalassemia and nasopharyngeal carcinoma: A case report and literature review, J Cancer Res Ther 2015, 11(4):1034.

4. Gaurav Pandey and Hiralal, Paraspinal mass in thalassaemia is often extramedullary haematopoiesis, Indian J Med Res 2015 , 142(5): 621–622.
Published
2016-04-29
How to Cite
CARVALHO, Rita; MAFRA, Manuela. How do I diagnose Extramedullary Hematopoiesis. Diagnostic Pathology, [S.l.], v. 2, n. 1, apr. 2016. ISSN 2364-4893. Available at: <http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/107>. Date accessed: 28 sep. 2020. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2016-2:107.
Section
How do I diagnose

Keywords

Extramedullary hematopoiesis; Extramedullary myeloid sarcoma; : Posterior mediastinum, para-vertebral mass; CD34, CD117, TdT

Most read articles by the same author(s)