History of the European Conference Series on Digital Pathology: Memories and Perspectives

  • Klaus Kayser Charite - Berlin

Abstract

Background

Digital pathology is based on both quantitative analysis of microscopic images and electronic communication (telepathology). Herein we report its development in close relationship to the European conference series on telepathology, virtual slides, and digital pathology that started in Heidelberg 26 years ago.

Telepathology, Virtual Microscopy and Digital Pathology

The author founded the conference series in Heidelberg in 1992, and has participated all of them. This report can give an insight of conferences’ information and data exchange in relation to available technological and medical knowledge. The digital world was still in its childhood at the date of the first conference. Most pathologists were not aware of its medical, technologic, and financial power at that time. Technological research and medical application investigated in electronic communication and digital acquisition of colored pictures. Frozen section services and its need for fast information transfer between different institutes and the surgical theatre dominated the application of technological development. Consecutively, all issues of telepathology were in focus at the start of and the following conferences. The pioneers of that time tried to convince their colleagues of the promising perspectives and the increasing technological influence on pathology. It took several conferences in this series until the majority of or nearly all pathologists recognized the power of this new technology. Retrospectively, some conferences remained at the scientific level of their preceding meetings, whereas others substantially promoted electronic (digital) knowledge and application in research and routine pathology.

Perspectives

At present, digital pathology is well implemented and mainly used for education and enhancement of molecular biology methods such as next generation sequencing, predictive diagnosis, or risk associated investigations. Implementation in routine diagnostic pathology (virtual slides, etc.) is on its way. Digital pathology seems to move forward to explore still unknown areas in surgical pathology, and tissue – based diagnosis. These include considerations on morphology, function and order of structures, which can detect potentially endangered factors or repair of live threatening breakdowns, as well as biostatistics, data mining, or self recognition algorithms.

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References

1. Weinstein, L.J., et al., Static image analysis of skin specimens: the application of telepathology to frozen section evaluation. Hum Pathol, 1997. 28(1): p. 30-5.

2. Weinstein, R.S., Prospects for telepathology. Hum Pathol, 1986. 17(5): p. 433-4.

3. Weinstein, R.S., Telepathology comes of age in Norway. Hum Pathol, 1991. 22(6): p. 511-3.

4. Weinstein, R.S., Static image telepathology in perspective. Hum Pathol, 1996. 27(2): p. 99-101.

5. Weinstein, R.S., Time for a reality check. Arch Pathol Lab Med, 2008. 132(5): p. 777-80.

6. Weinstein, R.S., et al., Telepathology: a ten-year progress report. Hum Pathol, 1997. 28(1): p. 1-7.

7. Weinstein, R.S., et al., Telepathology overview: from concept to implementation. Hum Pathol, 2001. 32(12): p. 1283-99.

8. Nordrum, I. and T.J. Eide, Remote frozen section service in Norway. Arch Anat Cytol Pathol, 1995. 43(4): p. 253-6.

9. Nordrum, I., et al., Remote frozen section service: a telepathology project in northern Norway. Hum Pathol, 1991. 22(6): p. 514-8.

10. Nordrum, I., et al., Diagnostic accuracy of second-opinion diagnoses based on still images. Hum Pathol, 2004. 35(1): p. 129-35.

11. Gundersen, H.J., Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc, 1986. 143(Pt 1): p. 3-45.

12. Gundersen, H.J., et al., Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. Apmis, 1988. 96(5): p. 379-94.

13. Gundersen, H.J. and R. Osterby, Optimizing sampling efficiency of stereological studies in biology: or 'do more less well!' J Microsc, 1981. 121(Pt 1): p. 65-73.

14. Mattfeldt, T., et al., Stereology of myocardial hypertrophy induced by physical exercise. Virchows Arch A Pathol Anat Histopathol, 1986. 409(4): p. 473-84.

15. Mattfeldt, T., et al., Estimation of surface area and length with the orientator. J Microsc, 1990. 159(Pt 3): p. 301-17.

16. Weibel, E.R., An automatic sampling stage microscope for stereology. J Microsc, 1970. 91(1): p. 1-18.

17. Weibel, E.R., Selection of the best method in stereology. J Microsc, 1974. 100(3): p. 261-9.

18. Weibel, E.R., Quantitation in morphology: possibilities and limits. Beitr Pathol, 1975. 155(1): p. 1-17.

19. Sanfeliu, A., K.S. Fu, and J. Prewitt, An application of distance measure between graphs to the analysis of muscle tissue pattern recognition. Saragota Springs Meeting, Proc., 1981: p. 86-89.

20. Kayser, K. and H. Stute, Minimum spanning tree, Voronoi's tesselation and Johnson-Mehl diagrams in human lung carcinoma. Pathol Res Pract, 1989. 185(5): p. 729-34.

21. Kayser, K. and H. Stute, DNA content and minimum spanning tree in primary and metastatic adenocarcinoma of the lung. Acta Stereol, 1989. 8/2: p. 117-121.

22. Kayser, K., et al., Combined morphometrical and syntactic structure analysis as tools for histomorphological insight into human lung carcinoma growth. Anal Cell Pathol, 1990. 2(3): p. 167-78.

23. Kayser, K., H. Stute, and W. Ebert, Analysis of branching points and minimum distance between neighboring cells in primarey bronchus carcinoma. Acta Stereol, 1987. 6/III: p. 207-212.

24. Kayser, K., et al., Neighborhood analysis of low magnification structures (glands) in healthy, adenomatous, and carcinomatous colon mucosa. Pathol Res Pract, 1986. 181(2): p. 153-8.

25. Kayser K, B.S., Djenouni A, Kayser G, Texture and object related image analysis in microscopic images. Diagnostic pathology, 2015. 1(14).

26. Miaoulis, G., et al., Telepathology in Greece. Experience of the Metaxas Cancer Institute. Zentralbl Pathol, 1992. 138(6): p. 425-8.

27. Weinstein, R.S., Telepathology: practicing pathology in two places at once. Clin Lab Manage Rev, 1992. 6(2): p. 171-3; discussion 174-5.

28. Becker, R.L., Jr., et al., Use of remote video microscopy (telepathology) as an adjunct to neurosurgical frozen section consultation. Hum Pathol, 1993. 24(8): p. 909-11.

29. Kayser, K., M. Drlicek, and W. Rahn, Aids of telepathology in intra-operative histomorphological tumor diagnosis and classification. In Vivo, 1993. 7(4): p. 395-8.

30. Oberholzer, M., et al., Telepathology with an integrated services digital network--a new tool for image transfer in surgical pathology: a preliminary report. Hum Pathol, 1993. 24(10): p. 1078-85.

31. Telepathology. 2nd European Conference. Paris-Dijon, 9,11 June 1994. Proceedings. Arch Anat Cytol Pathol, 1995. 43(4): p. 189-304.

32. Black-Schaffer, S. and T.J. Flotte, Current issues in telepathology. Telemed J, 1995. 1(2): p. 95-106.

33. Dietel, M., T.N. Nguyen-Dobinsky, and P. Hufnagl, The UICC Telepathology Consultation Center. International Union Against Cancer. A global approach to improving consultation for pathologists in cancer diagnosis. Cancer, 2000. 89(1): p. 187-91.

34. Dunn, B.E., et al., Use of telepathology for routine surgical pathology review in a test bed in the Department of Veterans Affairs. Telemed J, 1997. 3(1): p. 1-10.

35. Eide, T.J. and I. Nordrum, Current status of telepathology. Apmis, 1994. 102(12): p. 881-90.

36. Gall, J. and M. Lou Pardue, Formation and detection of RNA-DNA hybrid molecules in cytological preparations Proc. Natl. Acad. Sci. USA, 1969. 63(2): p. 378-383.

37. Ferrer-Roca, O., Telepathology and optical biopsy. Int J Telemed Appl, 2009. 2009: p. 740712.

38. Leong, F.J., et al., Clinical trial of telepathology as an alternative modality in breast histopathology quality assurance. Telemed J E Health, 2000. 6(4): p. 373-7.

39. Nordrum, I., V. Isaksen, and L. Arvola, Breast carcinoma diagnosed by telepathology. J Telemed Telecare, 1997. 3(3): p. 172-3.

40. Park, S., et al., The history of pathology informatics: A global perspective. J Pathol Inform, 2014. 4: p. 7.

41. Kayser, K., et al., History and structures of telecommunication in pathology, focusing on open access platforms. Diagn Pathol, 2011. 6: p. 110.

42. Massone, C., et al., Teledermatology: an update. Semin Cutan Med Surg, 2008. 27(1): p. 101-5.

43. Williams, B.H., et al., A national treasure goes online: the Armed Forces Institute of Pathology. MD Comput, 1998. 15(4): p. 260-5.

44. Della Mea, V., 25 years of telepathology research: a bibliometric analysis. Diagn Pathol, 2013. 6 Suppl 1: p. S26.

45. Kayser, K., et al., New developments in digital pathology: from telepathology to virtual pathology laboratory. Stud Health Technol Inform, 2004. 105: p. 61-9.

46. Kayser, K., et al., Image standards in Tissue-Based Diagnosis (Diagnostic Surgical Pathology). Diagn Pathol, 2008. 3: p. 17.

47. Lopez, A.M., et al., Virtual slide telepathology enables an innovative telehealth rapid breast care clinic. Semin Diagn Pathol, 2009. 26(4): p. 177-86.

48. Graham, A.R., et al., Virtual slide telepathology for an academic teaching hospital surgical pathology quality assurance program. Hum Pathol, 2009. 40(8): p. 1129-36.

49. Della Mea, V., Telepathology and the Internet. Telemed Today, 1999. 7(4): p. 17-8, 44.

50. Della Mea, V. and C.A. Beltrami, Diagnostic telepathology through the Internet. Histopathology, 1998. 33(5): p. 485.

51. Demichelis, F., et al., Robotic telepathology for intraoperative remote diagnosis using a still-imaging-based system. Am J Clin Pathol, 2001. 116(5): p. 744-52.

52. Eichhorn, J.H., et al., Internet-based gynecologic telecytology with remote automated image selection: results of a first-phase developmental trial. Am J Clin Pathol, 2008. 129(5): p. 686-96.

53. Ford, J.C., et al., Pathology education in a multisite urban/rural distributed curriculum. Hum Pathol, 2008. 39(6): p. 811-6.

54. Kayser K, Starting a new peer reviewed open access journal diagnosticpathology.eu. Diagnostic pathology, 2015. 1(1).

55. Weinstein, R.S., et al., Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future. Hum Pathol, 2009. 40(8): p. 1057-69.

56. Weinstein, R.S., Innovations in medical imaging and virtual microscopy. Hum Pathol, 2005. 36(4): p. 317-9.

57. Kayser, K., Travels on Conferences - Evolution of Digital Pathology. 2016, Berlin: Schaefermueller publishing.

58. Coons, A., H. Creech, and R. Jones, Immunological properties of an antibody containing a fluorescent group. Proc Soc Exp Biol Med, 1941. 47: p. 200 - 202.
Published
2016-08-09
How to Cite
KAYSER, Klaus. History of the European Conference Series on Digital Pathology: Memories and Perspectives. Diagnostic Pathology, [S.l.], v. 2, n. 1, aug. 2016. ISSN 2364-4893. Available at: <http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/201>. Date accessed: 29 mar. 2024. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2016-2:201.
Section
Review Articles

Keywords

European Conference on Telepathology; Digital Pathology; Telepathology; Virtual Slides