Expression of PTEN and pAKT in Non-Small Cell Lung Cancer

  • Gian Kayser, MD Institute of Surgical Pathology, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany
  • Carina Antfang, MD Institute of Surgical Pathology, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany
  • Agnes Csanadi, MD Institute of Surgical Pathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Abstract

Background: Alterations in the PTEN-AKT pathway play important roles indifferent solid carcinomas, e. g. of the breast, prostate and GI-tract. Since contradictory results have been reported for lung cancer mostly studying only one of the two proteins, we aim to elucidate the biological effects of alterations in this pathway in a large and well characterized cohort of non-small cell lung cancer.
Material and Methods: We established an immunohistochemical double stain for PTEN and p-AKT in non-small cell lung carcinomas (NSCLC). This was applied to tissue-microarrays (TMA) including 44 patients.
Results: Our results indicate, that not only alterations in one marker are of biological significance but rather the combination of PTEN-loss and p-AKT overexpression, as well as the intracellular localization of the protein staining. Patients with low-grade histological differentiation, negative lymphonodal status and PTEN-expression showed a significant better overall survival.
Conclusion: We conclude, that PTEN-(over-)expression leads to p-AKT downregulation with better overall survival in nodal negative NSCLC patients.
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Published
2019-08-22
How to Cite
KAYSER, MD, Gian; ANTFANG, Carina; CSANADI, Agnes. Expression of PTEN and pAKT in Non-Small Cell Lung Cancer. Diagnostic Pathology, [S.l.], v. 5, n. 1, aug. 2019. ISSN 2364-4893. Available at: <http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/272>. Date accessed: 17 sep. 2019. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2019-5:272.
Section
Short Report