Pituicytoma- Case Report Of A Rare Sellar/ Suprasellar Mass

  • Sandeep Mani Apollo Hospitals
  • Archana Lakshmanan Apollo cancer centre, Chennai
  • Annapurneswari Subramanyan Apollo cancer centre, Chennai


Background: Pituicytoma is a rare primary tumor of the sellar and suprasellar region, arising from the pituicytes which are specialized glial cells in the neurohyphophysis and infundibulum.  

Objective: Radiological features being non- specific, histopathological examination and immunohistochemistry will help us in arriving at the correct diagnosis.

Material and methods: We report a case of pituicytoma in a 48 year old woman arising in the sellar/suprasellar region.

Results: Histopathological examination of the lesion showed elongate bipolar spindle cells arranged in fascicular and storiform pattern. The neoplastic cells were diffusely positive for TTF-1, S-100, vimentin, variably positive for GFAP, negative for synaptophysin and Ki-67 index was less than one percentage.

Conclusion: Pituicytomas are rare tumors of the sellar and suprasellar region and its diagnosis is typically based on histopathological examination with a varied immunohistochemical profiles but with consistent TTF-1 positivity.


Download data is not yet available.

Author Biographies

Archana Lakshmanan, Apollo cancer centre, Chennai

Consultant pathologist,

Apollo cancer centre, Chennai.

Annapurneswari Subramanyan, Apollo cancer centre, Chennai

Chief of surgical pathology,

Apollo cancer centre, Chennai


1. Viaene, Angela N., et al. “Histologic, Immunohistochemical, and Molecular Features of Pituicytomas and Atypical Pituicytomas.” Acta Neuropathologica Communications, vol. 7, no. 1, Dec. 2019, p. 69. DOI.org (Crossref), https://doi.org/10.1186/s40478-019-0722-6.
2. Ulm, Arthur J., et al. “Pituicytoma: Report of Two Cases and Clues Regarding Histogenesis.” Neurosurgery, vol. 54, no. 3, Mar. 2004, pp. 753–58. DOI.org (Crossref), https://doi.org/10.1227/01.NEU.0000108983.50966.B7.
3. Brat, Daniel J., et al. “Pituicytoma: A Distinctive Low-Grade Glioma of the Neurohypophysis.” The American Journal of Surgical Pathology, vol. 24, no. 3, Mar. 2000, pp. 362–68. DOI.org (Crossref), https://doi.org/10.1097/00000478-200003000-00004.
4. Yang, Xiaoyu, et al. “Pituicytoma: A Report of Three Cases and Literature Review.” Oncology Letters, vol. 12, no. 5, Nov. 2016, pp. 3417–22. DOI.org (Crossref), https://doi.org/10.3892/ol.2016.5119.
5. Chakraborti, S., et al. “Pituicytoma: Report of Three Cases with Review of Literature.” Pathology - Research and Practice, vol. 209, no. 1, Jan. 2013, pp. 52–58. DOI.org (Crossref), https://doi.org/10.1016/j.prp.2012.10.006.
6. Figarella-Branger, D., et al. “Pituicytomas, a Mis-Diagnosed Benign Tumor of the Neurohypophysis: Report of Three Cases.” Acta Neuropathologica, vol. 104, no. 3, Sept. 2002, pp. 313–19. DOI.org (Crossref), https://doi.org/10.1007/s00401-002-0557-1.
7. Mao, Zhigang, et al. “Pituicytoma: Report of Two Cases.” Oncology Letters, vol. 2, no. 1, Jan. 2011, pp. 37–41. DOI.org (Crossref), https://doi.org/10.3892/ol.2010.209.
8. Hammoud, Dima A., et al. “Magnetic Resonance Imaging Features of Pituicytomas: Analysis of 10 Cases.” Journal of Computer Assisted Tomography, vol. 34, no. 5, Sept. 2010, pp. 757–61. DOI.org (Crossref), https://doi.org/10.1097/RCT.0b013e3181e289c0.
9. Nakasu, Yoko, et al. “Pituicytoma-Two Case Reports-: —Two Case Reports—.” Neurologia Medico-Chirurgica, vol. 46, no. 3, 2006, pp. 152–56. DOI.org (Crossref), https://doi.org/10.2176/nmc.46.152.
10. Uesaka, M. Miyazono, S. Nishio, T., T. “Astrocytoma of the Pituitary Gland (Pituicytoma): Case Report.” Neuroradiology, vol. 44, no. 2, Feb. 2002, pp. 123–25. DOI.org (Crossref), https://doi.org/10.1007/s002340100654.
How to Cite
MANI, Sandeep; LAKSHMANAN, Archana; SUBRAMANYAN, Annapurneswari. Pituicytoma- Case Report Of A Rare Sellar/ Suprasellar Mass. Diagnostic Pathology, [S.l.], v. 7, n. 1, mar. 2022. ISSN 2364-4893. Available at: <http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/284>. Date accessed: 28 may 2022. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2022-7:284.
Case Report