Diffuse Lipomatosis of Thyroid Gland. Case Report and Review of Literature.

  • Daniela Flamur Xhemalaj university hospital
  • Elona Xhardo Endocrinologist
  • Fadil Gradica
  • Leart Berdica

Abstract

In normal thyroid glands, adipose tissue is distributed only under the capsule and along vessels.It is not usually present within the thyroid gland. Only a few adipose tissue -containing thyroid lesions have been reported to date.


Lipomatosis of thyroid gland is very rare  condition,characterized by infiltration of adipose tissue in the thyroid gland.The pathophysiology of adipose tissue infiltration in the thyroid gland remains unclear.


We report a case of a 69-year-old female who presented in the Emergency Room of our hospital, complaining dysphaghia,dyspnea ,swelling of the neck and weight loss.


Her thyroid panel tests were in the range,ultrasound showed  the typical appearance of  multinodular goiter.A computed tomography revealed a rightward tracheal deviation and compression narrowing the tracheal  lumen more than 50%.


The patient underwent total thyroidectomy. The histopathological examination revealed that adipose tissue was diffusely distributed throughout the thyroid gland.There is no evidence of atypia or mitotic activity.


Capsular infiltration or amyloid deposition were not observed. Nuclear grooves or intranuclear cytoplasmic inclusions were not observed. Accordingly, diffuse lipomatosis of thyroid gland was diagnosed.

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References

1. Gnepp DR, Ogorzalek JM and Heffess CS: Fat-containing lesions of the thyroid gland. Am J Surg Pathol 13: 605-612, 1989

2. Endocrinol Diabetes Metab Case Rep. 2016; 2016: 160007.
Published online 2016 Mar 30. doi: 10.1530/EDM-16-0007

3. Dhayagude, R.G., Massive, A. and Dinda, A.K. (2009) Diffuse Lipomatosis of the Thyroid gland: A Pathologic Curiosity. Indian Journal of Pathology and Microbiology, 52, 215-216. https://doi.org/10.4103/0377-4929.48922

4. Ge Y, Luna MA, Cowan DF, Truong LD and Ayala AG: Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature. Ann Diagn Pathol 13: 384-389, 2009

5. Sanuvada RV, Chowhan AK, Rukmangadha N, Patnayak R, Yootla M & Amancharla LY. 2014. Thyrolipomatosis: an inquisitive rare entity. Gland Surgery 3 6–9

6. Arslan A, Alic B, Uzunlara AK, Buyukbayrama H & Sarı I 1999 Diffuse lipomatosis of thyroid gland. Auris, Nasus, Larynx 26 213–215. (doi:10.1016/S0385-8146(98)00049-2)

7. Schroder S & Bocker W 1985 Lipomatous lesions of the thyroid gland: a review. Applied Pathology 3 140–149

8. Lau E, Freitas P, Costa J, Batista R, Ma´ximo V, Coelho R, Matos-Lima L, Eloy C & Carvalho D 2015 Loss of mitochondrial SDHB expression: what is its role in diffuse thyroid lipomatosis? Hormone and Metabolic Research 47 165–167. (doi:10.1055/s-0034-1398559.

9. Gonulalan G, Esen H, Erikoglu M & Cakir M 2012 Thyroid lipomatosis. Internal Medicine 51 3383–3385. (doi:10.2169/internalmedicine.51.6765)
Published
2022-04-08
How to Cite
XHEMALAJ, Daniela Flamur et al. Diffuse Lipomatosis of Thyroid Gland. Case Report and Review of Literature.. Diagnostic Pathology, [S.l.], v. 7, n. 1, apr. 2022. ISSN 2364-4893. Available at: <http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/285>. Date accessed: 15 aug. 2022. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2022-7:285.
Section
Case Report