How do I diagnose Pagetoid Bowen Disease

  • Rita do Espírito Santo Carvalho Central Lisbon Hospital Center - Department of Pathology

Abstract

Bowen disease is a variant of squamous carcinoma in situ, which sometimes presents with a pagetoid growth pattern with cytologically atypical clear cells. In that case, the differencial diagnosis includes Paget disease and melanoma in situ, as well as less common entities. Here we describe a case where histological differenciation is difficult and immunohistochemical studies are necessary to make a diagnosis. Here we also highlight the heterogeneity of CK7 expression and the apparent specific expression of p63 in Pagetoid Bowen Disease.

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Author Biography

Rita do Espírito Santo Carvalho, Central Lisbon Hospital Center - Department of Pathology
Pathology Resident

References

1. Williamson, John D., et al., Pagetoid bowen disease: a report of 2 cases that express cytokeratin 7, Archives of pathology laboratory medicine 2000, 124:3, 427-430.
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3. Misago N, Toda S, Narisawa Y, Heterogeneity of cytokeratin 7 expression in pagetoid Bowen’s disease., Journal of Cutaneous Pathology 2012, 39, 724-726.

4. Sah SP, Kelly PJ, McManus DT, McCluggage WG, Diffuse CK7, CAM5.2 and BerEP4 positivity in pagetoid squamous cell carcinoma in situ (pagetoid Bowen’s disease) of the perianal region: a mimic of extramammary Paget’s disease., Histopathology 2013, 62, 511-524.
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6. Patterson, James W., “Nonmelanocytic Tumors of the Skin (Atlas of Tumor Pathology Series IV)”. 1st ed., American Registry of Pathology, 2006, 4: 32-35.
Published
2015-11-08
How to Cite
CARVALHO, Rita do Espírito Santo. How do I diagnose Pagetoid Bowen Disease. Diagnostic Pathology, [S.l.], nov. 2015. ISSN 2364-4893. Available at: <http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/88>. Date accessed: 26 nov. 2020. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2015-1:88.
Issue
Section
How do I diagnose

Keywords

Paget Disease; elastotic degeneration; Skin; p63