How do I diagnose Pagetoid Bowen Disease
Abstract
Bowen disease is a variant of squamous carcinoma in situ, which sometimes presents with a pagetoid growth pattern with cytologically atypical clear cells. In that case, the differencial diagnosis includes Paget disease and melanoma in situ, as well as less common entities. Here we describe a case where histological differenciation is difficult and immunohistochemical studies are necessary to make a diagnosis. Here we also highlight the heterogeneity of CK7 expression and the apparent specific expression of p63 in Pagetoid Bowen Disease.
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References
2. Mai KT, Alhalouly T, Landry D, et al., Pagetoid variant of actinic keratosis with or without squamous cell carcinoma of sun-exposed skin: a lesion simulating extramammary Paget’s disease. , Histopathology 2002, 41, 331–6.
3. Misago N, Toda S, Narisawa Y, Heterogeneity of cytokeratin 7 expression in pagetoid Bowen’s disease., Journal of Cutaneous Pathology 2012, 39, 724-726.
4. Sah SP, Kelly PJ, McManus DT, McCluggage WG, Diffuse CK7, CAM5.2 and BerEP4 positivity in pagetoid squamous cell carcinoma in situ (pagetoid Bowen’s disease) of the perianal region: a mimic of extramammary Paget’s disease., Histopathology 2013, 62, 511-524.
5. Rosai, J., ed. “Rosai and Ackerman´s Surgical Pathologyâ€Â. 10th ed, Elsevier, 2011, 1: 130-131; 143-144.
6. Patterson, James W., “Nonmelanocytic Tumors of the Skin (Atlas of Tumor Pathology Series IV)â€Â. 1st ed., American Registry of Pathology, 2006, 4: 32-35.
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