2024-03-29T11:59:58Z
http://www.diagnosticpathology.eu/content/index.php/dpath/oai
oai:ojs2.localhost:article/100
2018-06-19T09:04:46Z
dpath:CAS
nmb a2200000Iu 4500
"160204 2016 eng "
2364-4893
dc
Low Grade Well-circumscribed Well Differentiated Liposarcoma Developed in Fibroadenoma with Stromal adipose differentiation of the Breast; A Case Report
Ayad, Essam
Cairo University + Italian Hospital - Cairo
Breast Fibroadenoma; Stromal Adipose differentiation; Well-differentiated liposarcoma.
Fibroadenomas are the most common breast tumor in adolescents and young women.They comprise  20% of benign breast masses and 12% of all breast masses in postmenopausal women. Smooth muscle metaplasia and adipose differentiation are uncommon forms of stromal differentiation encountered in a minority of fibroadenomas. Liposarcoma can arise from pre-existing benign lesions like phylloides tumour or from lipoid tissue in the breast. In this article we present a case of 38 year-old female who presented with a right breast mass which was clinically diagnosed as a case of fibroadenoma, but histologically showed a low grade well-circumscribed liposarcoma discovered in a pericanalicular type of fibroadenoma with stromal adipose differentiation. According to our knowledge, this the first case of a well-circumscribed liposarcoma arises in fibroadenoma of the breast.
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Virtual Slides: www.diagnosticpathology.eu/vs/2016_2_100/
DiagnomX GmbH
2016-01-17 11:46:24
application/pdf
http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/100
Diagnostic Pathology; Vol 2 No 1 (2016): 2016
eng
##submission.copyrightStatement##
oai:ojs2.localhost:article/8
2018-06-19T09:07:29Z
dpath:CAS
nmb a2200000Iu 4500
"150407 2015 eng "
2364-4893
dc
Mucous gland adenoma of a segment bronchus - Case report
Mijovic, Zaklina Zarko
Medical Faculty, University of Nis
Mihailovic, Dragan
Medical Faculty, University of Nis
Zivkovic, Nikola
Medical Faculty, University of Nis
Stankovic, Milos
Medical Faculty, University of Nis
Kostov, Milos
Medical Faculty, University of Nis
Bronchus adenoma; endoscopy; immunohistochemistry; video-assisted thoracic surgery; prognosis
Background
Mucous gland adenoma of the bronchus is a rare benign epithelial tumor. The majority arises from the submucosal seromucous glands and ducts of the proximal airways. In bronchus biopsy specimen it might be difficult to distinguish mucous gland adenomas from low-grade malignant tumors, such as carcinoids, mucoepidermoid carcinomas, or adenoid cystic carcinomas. Complete tumor resection serves for both definite diagnosis and potential curative treatment.
Case
A non smoking man of 78 years suffered from cough, dyspnea and recently from hemoptysis. Fiberoptic bronchoscopy revealed a polypoid, well-circumscribed mass in the right posterior segmental bronchus. A bronchoscopic tumor excision was performed.
Histology and immunohistochemistry (IHC)
The tumor displayed with exuberant dilated cystic glands lined by columnar, cuboidal or flattened mucus secreting cells. IHC was positive for EMA, CKAE1/AE3, and negative for TTF1.
Conclusion
Uncommon benign bronchus adenomas should be taken into account in addition to the common malignant lung carcinomas with endobronchial growth pattern. Endoscopic tumor excision of bronchus adenomas is indicated for potential curative treatment, especially in patients of higher age.
DiagnomX GmbH
2015-01-08 17:32:29
application/pdf
http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/8
Diagnostic Pathology; 2015
eng
##submission.copyrightStatement##
oai:ojs2.localhost:article/261
2018-12-21T18:37:02Z
dpath:CAS
nmb a2200000Iu 4500
"180323 2018 eng "
2364-4893
dc
Primary neuroendocrine tumor of the breast - report of 2 cases
Fónyad, László
1st Department of Pathology and Experimental Cancer Research, Semmelweis University
Piros, László
Department of Transplantation and Surgery, Semmelweis University
Arató, Gabriella
1st Department of Pathology and Experimental Cancer Research, Semmelweis University
Kulka, Janina
2nd Department of Pathology, Semmelweis University
Background: Primary neuroendocrine tumor of the breast is rare, although 20-30% of primary breast carcinomas show neuroendocrine differentiation to some degree. According to the 2012 WHO Classification of Tumours of the Breast the current classification recognizes 3 subgroups of breast tumors with neuroendocrine features: Neuroendocrine tumor, well-differentiated; Neuroendocrine tumor, poorly-differentiated; Invasive breast carcinoma with neuroendocrine differentiation. Due to the low prevalence of this disease our understanding of its development, prognosis and effective therapy is limited. Up to date there are approximately 125 cases reported in the English and non-English literature. Here we report two further cases.
Material-Methods Our first patient was 63 years old and presented with a 3 cm large mobile nodule in the upper outer quadrant of her right breast. After a complete clinicopathological work-up of imaging techniques and core needle biopsy with an initial diagnosis of invasive carcinoma of no special type (IBC NST), lumpectomy and sentinel node biopsy was recommended by the institutional tumor board. The second patient was 75 years old and presented with a 2 cm large mobile nodule in the upper outer quadrant of her left breast. Lumpectomy was performed based on fine needle aspiration cytology results that revealed the malignant proliferation.
Results: Histological examination of the surgical specimens revealed neuroendocrine differentiation in approximately 90% of the tumor cells in both cases. Immunohistochemical studies and additional imaging studies disclosed the possibility of metastasis to the breast.
Disscussion: Neuroendocrine differentiation of breast tumors is a controversial issue and there are numerous questions in terms of histogenesis, diagnostics and clinical considerations. To establish the correct diagnosis, characteristic growth patterns and cytological and immunohistochemical features of neuroendocrine differentiation should be carefully evaluated.
DiagnomX GmbH
2018-01-23 00:00:00
application/pdf
http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/261
Diagnostic Pathology; Vol 4 No 1 (2018): 2018
eng
##submission.copyrightStatement##
oai:ojs2.localhost:article/10
2018-06-19T09:07:29Z
dpath:CAS
nmb a2200000Iu 4500
"150526 2015 eng "
2364-4893
dc
Cryptosporidiosis in an Immunocompetent Individual An unusual case with brief review of the literature
Jin, Bo
Wayne State University
Sinai Grace Hospital/ Detroit Medical Center
Yashpal, Anveil
Medical University of the Americas
Deol, Nisha
Medical University of the Americas
AbuRashed, Ahmed
Medical University of the Americas
Saleh, Husain
cryptosporidiosis, immunocompetent, chronic diarrhea
Cryptosporidiosis infection involves most commonly the small intestine but can occur in any part of the gastrointestinal (GI) tract. Typical infection by this parasitic organism occurs in immunocompromised individuals. However, rare cryptosporidiosis in immunocompetent individuals has been reported. Herein, we describe a case of cryptosporidiosis in an 85-year old woman who has hypertensive heart disease and diabetes, but is otherwise immunocompetent. This patient had protracted chronic diarrhea, however, medical workup failed to identify the etiology of this diarrhea.
Awareness of the possibility that cryptosporidiosis can involve immunocompetent individuals should be kept in mind among healthcare professionals to avoid misdiagnosis or lengthy delay in identifying the cause of the diarrhea or other GI illness. In particular, obtaining biopsy of the small or large intestines by the examining gastroenterologists in spite of normal endoscopy is very important to establish the diagnosis.
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DiagnomX GmbH
2015-01-08 17:32:29
application/pdf
http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/10
Diagnostic Pathology; 2015
eng
##submission.copyrightStatement##
oai:ojs2.localhost:article/284
2022-04-08T14:52:45Z
dpath:CAS
nmb a2200000Iu 4500
"220331 2022 eng "
2364-4893
dc
Pituicytoma- Case Report Of A Rare Sellar/ Suprasellar Mass
Mani, Sandeep
Apollo Hospitals
Lakshmanan, Archana
Apollo cancer centre, Chennai
Subramanyan, Annapurneswari
Apollo cancer centre, Chennai
Background: Pituicytoma is a rare primary tumor of the sellar and suprasellar region, arising from the pituicytes which are specialized glial cells in the neurohyphophysis and infundibulum.
Objective: Radiological features being non- specific, histopathological examination and immunohistochemistry will help us in arriving at the correct diagnosis.
Material and methods: We report a case of pituicytoma in a 48 year old woman arising in the sellar/suprasellar region.
Results: Histopathological examination of the lesion showed elongate bipolar spindle cells arranged in fascicular and storiform pattern. The neoplastic cells were diffusely positive for TTF-1, S-100, vimentin, variably positive for GFAP, negative for synaptophysin and Ki-67 index was less than one percentage.
Conclusion: Pituicytomas are rare tumors of the sellar and suprasellar region and its diagnosis is typically based on histopathological examination with a varied immunohistochemical profiles but with consistent TTF-1 positivity.
DiagnomX GmbH
2022-03-31 16:45:51
application/pdf
http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/284
Diagnostic Pathology; Vol 7 No 1 (2022): Vol 7 No 1
eng
##submission.copyrightStatement##
oai:ojs2.localhost:article/28
2018-06-19T09:06:22Z
dpath:CAS
nmb a2200000Iu 4500
"150720 2015 eng "
2364-4893
dc
A case of renal cell carcinoma with abundant smooth muscle (leiomyomatous) stroma and the differential diagnosis
Abrantes, Carlos Filipe
IPO - Instituto Português de Oncologia
CHUC - Centro Hospitalar e Universitário de Coimbra
Oliveira, Rui Caetano
Department of Anatomical Pathology, Hospital of the University of Coimbra (CHUC), Portugal
Sepúlveda, LuÃs
Department of Anatomical Pathology, Hospital of the University of Coimbra (CHUC), Portugal
Figueiredo, Arnaldo
Department of Anatomical Pathology, Hospital of the University of Coimbra (CHUC), Portugal
Marinho, Carol
Department of Urology and Renal Transplantation, Hospital of the University of Coimbra (CHUC), Portugal
Sousa, VÃtor
Department of Urology and Renal Transplantation, Hospital of the University of Coimbra (CHUC), Portugal
Castro, LÃgia Prado e
Department of Urology and Renal Transplantation, Hospital of the University of Coimbra (CHUC), Portugal
Kidney, Renal cell carcinoma, Clear cells, Leiomyomatous stroma
Renal cell carcinoma with smooth muscle stroma (RCCSMS) is a rare and controversial renal cancer type with indolent behavior. This separation of this entity from other types of renal cell carcinoma is supported by recent published studies but not yet recognized by the World Health Organization. We present a case of a 72 years old female, with incidental finding on abdominal ultrasound of a renal nodule with 1.5cm. The patient underwent partial nephrectomy and the pathological evaluation showed an epithelial tumor composed of nests and trabeculae of polygonal cells with clear cytoplasm and low grade nuclear features, surrounded by an abundant stroma composed by fascicles of spindle cells without significant pleomorphism or mitoses. Immunohistochemically, the epithelial cells showed strong and diffuse positivity for CK7, CD10, vimentin and EMA; staining for RCC was focal. The stromal cells were positive for vimentin, smooth muscle actin, HHF35, desmin and caldesmon; ER and PR were negative. The staining for HMB45 and Melan-A was negative in both components. So the final diagnosis of RCCSMS was made. It’s important to be aware of this entity in order to differentiate RCCSMS from renal cancers with less favorable prognosis and higher degree of malignancy, like clear cell renal cell carcinoma, especially with sarcomatoid change.
DiagnomX GmbH
2015-01-08 17:32:29
application/pdf
http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/28
Diagnostic Pathology; 2015
eng
##submission.copyrightStatement##
oai:ojs2.localhost:article/285
2022-04-08T14:54:52Z
dpath:CAS
nmb a2200000Iu 4500
"220408 2022 eng "
2364-4893
dc
Diffuse Lipomatosis of Thyroid Gland. Case Report and Review of Literature.
Xhemalaj, Daniela Flamur
university hospital
Xhardo, Elona
Endocrinologist
Gradica, Fadil
Berdica, Leart
In normal thyroid glands, adipose tissue is distributed only under the capsule and along vessels.It is not usually present within the thyroid gland. Only a few adipose tissue -containing thyroid lesions have been reported to date.
Lipomatosis of thyroid gland is very rare condition,characterized by infiltration of adipose tissue in the thyroid gland.The pathophysiology of adipose tissue infiltration in the thyroid gland remains unclear.
We report a case of a 69-year-old female who presented in the Emergency Room of our hospital, complaining dysphaghia,dyspnea ,swelling of the neck and weight loss.
Her thyroid panel tests were in the range,ultrasound showed the typical appearance of multinodular goiter.A computed tomography revealed a rightward tracheal deviation and compression narrowing the tracheal lumen more than 50%.
The patient underwent total thyroidectomy. The histopathological examination revealed that adipose tissue was diffusely distributed throughout the thyroid gland.There is no evidence of atypia or mitotic activity.
Capsular infiltration or amyloid deposition were not observed. Nuclear grooves or intranuclear cytoplasmic inclusions were not observed. Accordingly, diffuse lipomatosis of thyroid gland was diagnosed.
DiagnomX GmbH
2022-03-31 16:45:51
application/pdf
http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/285
Diagnostic Pathology; Vol 7 No 1 (2022): Vol 7 No 1
eng
##submission.copyrightStatement##
oai:ojs2.localhost:article/57
2018-06-19T09:06:22Z
dpath:CAS
nmb a2200000Iu 4500
"150721 2015 eng "
2364-4893
dc
Metastatic embryonal rhabdomyosarcoma to the breast: a case report and review of the literature
Zioga, Christina
Theagenio Anticancer Hospital of Thessaloniki, Greece http://orcid.org/0000-0003-1160-1410
Destouni, Chariklia
Theagenio Anticancer Hospital of Thessaloniki, Greece
breast, rhabdomyosarcoma, metastasis, fine needle aspiration, cytology
A 19-year-old fertile Caucasian female, with a medical history of embryonal rhabdomyosarcoma in the left upper extremity at the age of 17, presented with enlarged lymph node of left axilla. Fine needle aspiration (FNA) cytology of axillar lymph node revealed a metastatic malignant neoplasm, consistent with the primary embryonal rhabdomyosarcoma. Four months later, breast clinical examination revealed the presence of multiple hard and immobile masses located in both breasts. Ultrasound detected multiple opacity areas and ultrasound-guided FNA cytology was performed on two bilateral breast lumps. The final cytology diagnosis of FNA -using ThinPrep® technique- was “Positive morphologic and immunocytochemistry findings of metastatic malignant neoplasm of mesenchymal origin, consistent with patient’s history-embryonal rhabdomyosarcomaâ€. Today the patient is under first line chemotherapy and in good physical condition.
DiagnomX GmbH
2015-01-08 17:32:29
application/pdf
http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/57
Diagnostic Pathology; 2015
eng
##submission.copyrightStatement##
oai:ojs2.localhost:article/86
2018-06-19T09:01:16Z
dpath:CAS
nmb a2200000Iu 4500
"151030 2015 eng "
2364-4893
dc
Amelanotic metastasing melanoma mimicking lung cancer
Xhemalaj, Daniela Flamur
Department of pathology -University hospital of lung diseases-Tirana
Caushi, Fatmir
Department of Surgery-University Hospital of lung disease-Tirana
Ulazzi, Linda
Department of molecular Biology-Universita di Ferrara
Rinaldi, Rosa
Department of Pathology -Universita di Ferrara
Lanza, Giovanni
Deparment of patholology-Universita di Ferrara
Hafizi, Hasan
Head of Service of Pneumonology-University hospital center of lung diseases-Tirana
Alimehmeti, Mehdi
Head of Department of Pathology-University hospital Center-Tirana
Pumo, Gisela
Department of Pathology-University hospital Center-Tirana
Hasa, Asela
Department of Pathology-University hospital Center-Tirana
Malignant Melanoma, Lung metastasis, Immunohistochemistry, Lobectomy.
Lung is one of the most common site of metastasis in patients with malignant melanoma. We report a 64 year old man, who was submitted to our hospital. He complained of increasing intensity of shortage of breath, cough, and loss of weight within the last weeks. Serum analysis was normal. X-ray and CT images displayed a circumscribed density in the lower left lung, suspicious for lung cancer. Bronchoscopy and biopsy indicated a non differentiated malignancy which could not be further classified. Excision of the lower left lobe and of mediastinal lymph nodes was performed. The post surgical definite histological diagnosis revealed an amelanocytic epithelioid melanoma (positive for HMB-45, S-100). Pathologists, pulmonologists and thoracic surgeons should be aware of different cell types of intrapulmonary malignancies although primary lung cancer contributes to the outstanding majority of large and solid lung lesions.
DiagnomX GmbH
2015-01-08 17:32:29
application/pdf
http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/86
Diagnostic Pathology; 2015
eng
##submission.copyrightStatement##
oai:ojs2.localhost:article/7
2018-06-19T09:07:53Z
dpath:CAS
nmb a2200000Iu 4500
"150322 2015 eng "
2364-4893
dc
Mucinous tubular and spindle cell carcinoma of the kidney: case report with literature review
Oliveira, Rui Caetano
Centro Hospitalar e Universitário de Coimbra, Serviço de Anatomia Patológica
Silva, Edgar Tavares
Abrantes, Carlos
Rodrigues, Pedro
Marinho, Carol
Sousa, Vitor
Simoes, Pedro
Castro, Ligia Prado e
Spindle cell carcinoma; kidney cancer; papillary renal cell carcinoma; incidence; immunohistochemistry
Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a rare renal cancer type, recently recognized by the World Health Organization (WHO) in 2004, with indolent behavior. We present a case of a 50-year-old female that revealed a renal mass on an abdominal echography, incidentally discovered during a hepatic hemangioma follow-up. The patient underwent partial nephrectomy, and after pathological evaluation the final diagnosis of MTSCC was made. MSTCC is a special renal cancer type, with low degree of malignancy and a favorable prognosis. Surgical resection is the treatment of choice. It’s important to be aware of this entity in order to differentiate MTSCC with renal cancers of less favorable prognosis and higher degree of malignancy like papillary renal cell carcinoma.Â
DiagnomX GmbH
2015-01-08 17:32:29
application/pdf
http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/7
Diagnostic Pathology; 2015
eng
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