Morphometric study of facial wrinkles and aesthetic skin as dermaroller treatment combined with platelet rich plasma (PRP)
Abstract
Abstract
Background: Facial wrinkles are a multifactorial, complex process that negatively affects individuals’ appearance, consequently their quality of life. The treatment for these wrinkles varies with the degree of severity. This prospective study aimed to evaluate the clinical effect of pure dermaroller and dermaroller combined with platelet rich plasma therapy (PRP dermaroller), to treat facial wrinkles, and to quantitatively evaluate histological changes of the skin that occur in the two different cohorts.
Methods and materials: Twenty healthy women aged 43-48 years with scores ranging between 2 and 4 on the baseline facial fine wrinkle grading scale were enrolled in the this clinical study. Nineteen of the patients were treated with a pure dermaroller on the one half of face, and with a dermaroller that included a platelet rich plasma on the other half of the face. Three treatments, each in a 4 weeks interval were performed. Standard photographs and skin biopsies were obtained from the treatment area at baseline and 8 weeks after the final session. Comparisons of the treatments were analyzed using clinical and histological findings.
Results: The degree of baseline facial fine wrinkle grading scale after treatment revealed statistically significant effects of the PRP dermaroller treatment side compared to the side of pure dermaroller treatment. At 8 weeks after the final session, the wrinkling grade on the PRP dermaroller side and the pure dermaroller side showed significant differences (p<0.05). Microscopic evaluation of haematoxylin eosin and Masson’s trichrome stained sections revealed significant differences in dermal fibers, epidermal thickness, papillas and skin glands.
Conclusion: Significant changes were noted between treatments of facial wrinkles with pure dermaroller and PRP dermaroller. Dermaroller combined with platelet rich plasma is a promising novel method of facial rejuvenation.Â
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Fabbrocini, G., De Vita, V., Pastore, F., Annunziata, M.C., Caccuiapouti, S., Monfrecola, A., Cameli, N., Tosti, N., Collagen induction therapy for the treatment of upper lip wrinkles. Journal of Dermatological Treatment, 2012. 23:144–152.
El-Domyati, M., El-Ammawi, T.S., Moawad, O., El-Fakahany, H., Medhat, W., Mahoney MG, Uitto, J., Efficacy of mesotherapy in facial rejuvenation: a histological and immunohistochemical evaluation. Int J Dermatol, 2012. 51(8):913–919.
Gilchrest, B.A., A review of skin ageing and its medical therapy. British journal of dermatology, 1996. 135:867-875.
Aust, M.C., Fernandes, D., Kolokythas, P., Kaplan, H.M., Vogt, P.M., Percutaneous Collagen Induction Therapy: An Alternative Treatment for Scars, Wrinkles, and Skin Laxity. Plastic and Reconstructive Surgery,2008. 121(4):1421-9.
Rachel, J.D., Jamora, J. J., Skin Rejuvenation Regimens: a profilometry and histopathologic study. Arch Facial Plastic Surgery, 2003. 5(2):145-9.
Redaelli, A., Romano, D., Marcianó, A., Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol, 2010. 9(5): 466-472.
Yuksel, E.P., Sahin, G., Aydin, F., et al. Evaluation of effects of platelet rich plasma on human facial skin. Journal of Cosmetic and Laser Therapy, 2014. 16: 206–208.
Mehryan, P., Zartab, H., Rajabi, A., Pazhoohi, N., Firooz, A., Assessment of efficacy of platelet-rich plasma (PRP) on infraorbital dark circles and crow’s feet wrinkles. Journal of Cosmetic Dermatology, 2014. 13(1):72-78.
Man, D., Plosker, H., Winland-Brown, J.E., The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. Plast Reconstr Surg, 2001. 107(1):229-37.
Jeon, I.K., Chang, S.E., Park, G.H., Roh, M.R., Comparison of Microneedle Fractional Radiofrequency Therapy with Intradermal Botulinum Toxin A Injection for Periorbital Rejuvenation. J Dermatology, 2013. 227(4):367–372.
Lee, H.J., Lee, E.G., Kang, S., Sung, J.H., Chung H.M., Kim, D.H., Efficacy of Microneedling Plus Human Stem Cell Conditioned Medium for Skin Rejuvenation: A Randomized, Controlled, Blinded Split-Face Study. Ann Dermatol, 2014. 26(5):584-91.
El-Domyati, M., El-Ammawi, T.S., Medhat, W., et al. Electro-optical synergy technique: a new and effective non-ablative approach to skin aging. J Clin Aesthet Dermatol, 2010. 3:22–30.
Shin, M.K., Lee, J.H., Lee, S.J., Kim, N.I., Platelet-Rich Plasma Combined with Fractional Laser Therapy for Skin Rejuvenation. Dermatol. Surg, 2012. 38: 623–630.
Donnelly, R.F., Singh, T.R., Tunney, M.M., Morrow, D.I., McCarron, P.A., et al. Microneedle Arrays Allow Lower Microbial Penetration Than Hypodermic Needles In Vitro. Pharm Res, 2009. 26(11): 2513–2522.
Zeitter, S., Sikora, Z., Jahn, S., Stahl, F., Strau, S., Lazaridis, A., Reimers, K., Vogt, P.M., Aust, M.C., Microneedling: Matching the results of medical needling and repetitive treatments to maximize potential for skin regeneration. Burns, 2014. 40:966-973.
Dhillon, R.S., Schwarz, E.M., Maloney, M.D., Platelet-rich plasma therapy – future or trend? Arthritis Res Ther, 2012. 14: 219.
Anitua, E., Orive, G., Aguirre, J.J., Ardanza, B., Andia, I., 5 year clinical experience with BTI dental implants: risk factors for implant failure. J Clin Periodontol, 2008. 35:724 – 732.
DOI: http://dx.doi.org/10.17629/www.diagnosticpathology.eu-2017-3:238
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