How do I diagnose Pagetoid Bowen Disease

  • Rita do Espírito Santo Carvalho Central Lisbon Hospital Center - Department of Pathology

Abstract

Bowen disease is a variant of squamous carcinoma in situ, which sometimes presents with a pagetoid growth pattern with cytologically atypical clear cells. In that case, the differencial diagnosis includes Paget disease and melanoma in situ, as well as less common entities. Here we describe a case where histological differenciation is difficult and immunohistochemical studies are necessary to make a diagnosis. Here we also highlight the heterogeneity of CK7 expression and the apparent specific expression of p63 in Pagetoid Bowen Disease.

Downloads

Download data is not yet available.

Author Biography

Rita do Espírito Santo Carvalho, Central Lisbon Hospital Center - Department of Pathology
Pathology Resident

References

1. Williamson, John D., et al., Pagetoid bowen disease: a report of 2 cases that express cytokeratin 7, Archives of pathology laboratory medicine 2000, 124:3, 427-430.
2. Mai KT, Alhalouly T, Landry D, et al., Pagetoid variant of actinic keratosis with or without squamous cell carcinoma of sun-exposed skin: a lesion simulating extramammary Paget’s disease. , Histopathology 2002, 41, 331–6.

3. Misago N, Toda S, Narisawa Y, Heterogeneity of cytokeratin 7 expression in pagetoid Bowen’s disease., Journal of Cutaneous Pathology 2012, 39, 724-726.

4. Sah SP, Kelly PJ, McManus DT, McCluggage WG, Diffuse CK7, CAM5.2 and BerEP4 positivity in pagetoid squamous cell carcinoma in situ (pagetoid Bowen’s disease) of the perianal region: a mimic of extramammary Paget’s disease., Histopathology 2013, 62, 511-524.
5. Rosai, J., ed. “Rosai and Ackerman´s Surgical Pathology”. 10th ed, Elsevier, 2011, 1: 130-131; 143-144.

6. Patterson, James W., “Nonmelanocytic Tumors of the Skin (Atlas of Tumor Pathology Series IV)”. 1st ed., American Registry of Pathology, 2006, 4: 32-35.
Published
2015-11-08
How to Cite
CARVALHO, Rita do Espírito Santo. How do I diagnose Pagetoid Bowen Disease. Diagnostic Pathology, [S.l.], nov. 2015. ISSN 2364-4893. Available at: <https://www.diagnosticpathology.eu/content/index.php/dpath/article/view/88>. Date accessed: 29 mar. 2024. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2015-1:88.
Issue
Section
How do I diagnose

Keywords

Paget Disease; elastotic degeneration; Skin; p63