Metastatic embryonal rhabdomyosarcoma to the breast: a case report and review of the literature
A 19-year-old fertile Caucasian female, with a medical history of embryonal rhabdomyosarcoma in the left upper extremity at the age of 17, presented with enlarged lymph node of left axilla. Fine needle aspiration (FNA) cytology of axillar lymph node revealed a metastatic malignant neoplasm, consistent with the primary embryonal rhabdomyosarcoma. Four months later, breast clinical examination revealed the presence of multiple hard and immobile masses located in both breasts. Ultrasound detected multiple opacity areas and ultrasound-guided FNA cytology was performed on two bilateral breast lumps. The final cytology diagnosis of FNA -using ThinPrepÂ® technique- was â€œPositive morphologic and immunocytochemistry findings of metastatic malignant neoplasm of mesenchymal origin, consistent with patientâ€™s history-embryonal rhabdomyosarcomaâ€. Today the patient is under first line chemotherapy and in good physical condition.
2. Omranipour R, Hadi MR. Breast metastasis from multiple primary rhabdomyosarcoma in upper extremity. Clin Pract [Internet]. 2012 Jan 1 [cited 2014 May 18];2(1):e25. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3981328&tool=pmcentrez&rendertype=abstract
3. Rogers DA, Lobe TE, Rao BN, Fleming ID, Schropp KP, Pratt AS, et al. Breast malignancy in children. J Pediatr Surg [Internet]. 1994 Jan [cited 2014 May 18];29(1):48â€“51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8120761
4. Sheen-Chen S-M, Eng H-L, Ko S-F. Metastatic rhabdomyosarcoma to the breast. Anticancer Res [Internet]. [cited 2014 May 18];25(1B):527â€“9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15816623
5. Yaren A, Guclu A, Sen N, Erdem E, Demirkan F. Breast metastasis in a pregnant woman with alveolar rhabdomyosarcoma of the upper extremity. Eur J Obstet Gynecol Reprod Biol [Internet]. 2008 Sep [cited 2014 May 19];140(1):131â€“3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17869405
6. Bhosale SJ, Kshirsagar AY, Sulhyan SR, Sulhyan SR. Rhabdomyosarcoma of the breast - a rare malignancy. Am J Case Rep [Internet]. 2013 Jan [cited 2014 May 19];14:250â€“2. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3715332&tool=pmcentrez&rendertype=abstract
7. Li D-L, Zhou R-J, Yang W-T, Wang J, Yao X-H, Cheng Y-F, et al. Rhabdomyosarcoma of the breast: a clinicopathologic study and review of the literature. Chin Med J (Engl) [Internet]. 2012 Jul [cited 2014 May 19];125(14):2618â€“22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22882949
8. Keorochana G, Chanplakorn P, Laohacharoensombat W, Larbcharoensub N. Spinal and bilateral breast metastases of embryonal rhabdomyosarcoma. J Med Assoc Thai [Internet]. 2007 Apr [cited 2014 May 19];90(4):813â€“8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17487140
9. Binokay F, Soyupak SK, Inal M, Celiktas M, AkgÃ¼l E, Aksungur E. Primary and metastatic rhabdomyosarcoma in the breast: report of two pediatric cases. Eur J Radiol [Internet]. 2003 Dec [cited 2014 May 19];48(3):282â€“4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14652147
10. Lai CR, Hsu CY, Tsay SH, Hung-Chiang. Adult embryonal rhabdomyosarcoma metastatic to the breast and diagnosed by fine needle aspiration. A case report. Acta Cytol [Internet]. [cited 2014 May 19];41(3):845â€“8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9167712
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