Metastatic embryonal rhabdomyosarcoma to the breast: a case report and review of the literature

DOI: https://doi.org/10.17629/www.diagnosticpathology.eu-2015-1:57

Abstract

A 19-year-old fertile Caucasian female, with a medical history of embryonal rhabdomyosarcoma in the left upper extremity at the age of 17, presented with enlarged lymph node of left axilla. Fine needle aspiration (FNA) cytology of axillar lymph node revealed a metastatic malignant neoplasm, consistent with the primary embryonal rhabdomyosarcoma. Four months later, breast clinical examination revealed the presence of multiple hard and immobile masses located in both breasts. Ultrasound detected multiple opacity areas and ultrasound-guided FNA cytology was performed on two bilateral breast lumps. The final cytology diagnosis of FNA -using ThinPrep® technique- was “Positive morphologic and immunocytochemistry findings of metastatic malignant neoplasm of mesenchymal origin, consistent with patient’s history-embryonal rhabdomyosarcomaâ€. Today the patient is under first line chemotherapy and in good physical condition.

Downloads

Download data is not yet available.

Author Biographies

Christina Zioga, Theagenio Anticancer Hospital of Thessaloniki, Greece
Resident of Cytopathology
Chariklia Destouni, Theagenio Anticancer Hospital of Thessaloniki, Greece
Director of Cytopathology Department

References

1. Hays DM, Donaldson SS, Shimada H, Crist WM, Newton WA, Andrassy RJ, et al. Primary and metastatic rhabdomyosarcoma in the breast: neoplasms of adolescent females, a report from the Intergroup Rhabdomyosarcoma Study. Med Pediatr Oncol [Internet]. 1997 Sep [cited 2014 May 18];29(3):181–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9212842
2. Omranipour R, Hadi MR. Breast metastasis from multiple primary rhabdomyosarcoma in upper extremity. Clin Pract [Internet]. 2012 Jan 1 [cited 2014 May 18];2(1):e25. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3981328&tool=pmcentrez&rendertype=abstract
3. Rogers DA, Lobe TE, Rao BN, Fleming ID, Schropp KP, Pratt AS, et al. Breast malignancy in children. J Pediatr Surg [Internet]. 1994 Jan [cited 2014 May 18];29(1):48–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8120761
4. Sheen-Chen S-M, Eng H-L, Ko S-F. Metastatic rhabdomyosarcoma to the breast. Anticancer Res [Internet]. [cited 2014 May 18];25(1B):527–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15816623
5. Yaren A, Guclu A, Sen N, Erdem E, Demirkan F. Breast metastasis in a pregnant woman with alveolar rhabdomyosarcoma of the upper extremity. Eur J Obstet Gynecol Reprod Biol [Internet]. 2008 Sep [cited 2014 May 19];140(1):131–3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17869405
6. Bhosale SJ, Kshirsagar AY, Sulhyan SR, Sulhyan SR. Rhabdomyosarcoma of the breast - a rare malignancy. Am J Case Rep [Internet]. 2013 Jan [cited 2014 May 19];14:250–2. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3715332&tool=pmcentrez&rendertype=abstract
7. Li D-L, Zhou R-J, Yang W-T, Wang J, Yao X-H, Cheng Y-F, et al. Rhabdomyosarcoma of the breast: a clinicopathologic study and review of the literature. Chin Med J (Engl) [Internet]. 2012 Jul [cited 2014 May 19];125(14):2618–22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22882949
8. Keorochana G, Chanplakorn P, Laohacharoensombat W, Larbcharoensub N. Spinal and bilateral breast metastases of embryonal rhabdomyosarcoma. J Med Assoc Thai [Internet]. 2007 Apr [cited 2014 May 19];90(4):813–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17487140
9. Binokay F, Soyupak SK, Inal M, Celiktas M, Akgül E, Aksungur E. Primary and metastatic rhabdomyosarcoma in the breast: report of two pediatric cases. Eur J Radiol [Internet]. 2003 Dec [cited 2014 May 19];48(3):282–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14652147
10. Lai CR, Hsu CY, Tsay SH, Hung-Chiang. Adult embryonal rhabdomyosarcoma metastatic to the breast and diagnosed by fine needle aspiration. A case report. Acta Cytol [Internet]. [cited 2014 May 19];41(3):845–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9167712
Published
2015-07-21
How to Cite
ZIOGA, Christina; DESTOUNI, Chariklia. Metastatic embryonal rhabdomyosarcoma to the breast: a case report and review of the literature. Diagnostic Pathology, [S.l.], july 2015. ISSN 2364-4893. Available at: <http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/57>. Date accessed: 11 dec. 2024. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2015-1:57.
Citation Formats
Issue
2015
Section
Case Report

Keywords

breast, rhabdomyosarcoma, metastasis, fine needle aspiration, cytology
Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Authors who publish with this journal agree to the following terms:


1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

4. In case of virtual slide publication the authors agree to copy the article in a structural modified version to the journal's VS archive.

Most read articles by the same author(s)