Mucinous tubular and spindle cell carcinoma of the kidney: case report with literature review

  • Rui Caetano Oliveira Centro Hospitalar e Universitário de Coimbra, Serviço de Anatomia Patológica
  • Edgar Tavares Silva
  • Carlos Abrantes
  • Pedro Rodrigues
  • Carol Marinho
  • Vitor Sousa
  • Pedro Simoes
  • Ligia Prado e Castro

Abstract

Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a rare renal cancer type, recently recognized by the World Health Organization (WHO) in 2004, with indolent behavior. We present a case of a 50-year-old female that revealed a renal mass on an abdominal echography, incidentally discovered during a hepatic hemangioma follow-up. The patient underwent partial nephrectomy, and after pathological evaluation the final diagnosis of MTSCC was made. MSTCC is a special renal cancer type, with low degree of malignancy and a favorable prognosis. Surgical resection is the treatment of choice. It’s important to be aware of this entity in order to differentiate MTSCC with renal cancers of less favorable prognosis and higher degree of malignancy like papillary renal cell carcinoma. 

Downloads

Download data is not yet available.

Author Biography

Rui Caetano Oliveira, Centro Hospitalar e Universitário de Coimbra, Serviço de Anatomia Patológica

Resident of Pathology at University Hospital of Coimbra;

PhD Student at Faculty of Medicine of University of Porto

References

[1]http://www.cancerresearchuk.org/cancer- info/cancerstats/types/kidney/incidence/uk-kidney-cancer-incidence-statistics#geog (accessed in June 2014)

[2] Zhou M, Netto GJ, Epstein JI. Uropathology: High-Yield Pathology. Chapter G – Neoplastic Disease of the Kidney. People’s Republic of China: Elsevier-Sauders, 2012. Pp. 287-8.

[3] MacLennan GT, Farrow GM, Bostwick DG. Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. Urol, 1997 Nov, 50(5): 679-84.

[4] Eble JN: Mucinous tubular and spindle cell carcinoma and post-neuroblastoma carcinoma: newly recognized entities in renal cell carcinoma family. Pathology 2003, 35(6): 499-504

[5] Srigley JR. Mucinous tubular and spindle cell carcinoma. In: Eble JN, sauter G, eds. World Health Organization Classification of Tumor. Tumors of the Urinary System and Male Genital Organs. Lyon, France: International Agency for Research on Cancer, 2004. P. 40.

[6] Arafah M and Zaidi SN. Mucinous Tubular and Spindle Cell Carcinoma of the Kidney with Sarcomatoid Transformation. Saudi J Kidney Dis Transpl 2013, 24(3): 557-60

[7] Lima MS, Barros-Silva GE, Pereira R et al. The Imaging and Pathological Features of a Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: a Case Report. World Journal of Surgical Oncology, 2013. 11: 34

[8] Yang G, Breyer BN, Weiss D, MacLennan G. Mucinous Tubular and Spindle Cell carcinoma of the Kidney. J Urol, 2010. 183(2): 738-9

[9] Fine SW, Argani P, DeMarzo AM, Delahunt B, Sebo TJ, Reuter VE and Epstein JL. Expanding the Histologic Spectrum of Mucinous Tubular and Spindle Cell Carcinoma of the Kidney. Am J Surg Pathol, 2006. 30: 1554-60

[10] Saito K, Shimada M, Inoue K et al. A Case of Mucinous Tubular and Spindle Cell Carcinoma of the Kidney. Hinyokika Kiyo, 2013. 59(2): 107-11

[11] Sorrentino M, Bernardi S, Bruschi F et al. Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: a Rare Case Diagnosed in the Early Postpartum. Int J Surg Pathol, 2014. 22(7): 659-62

[12] Hes O, Hora M, Perez-Montiel DM et al. Spindle and Cuboid Cell Carcinoma, a Tumor Having Frequent Association with Nephrolithiasis: Report f 11 Cases Including a Case with Hybrid Conventional Renal Cell carcinoma/Spindle and Cuboidal Renal Cell Carcinoma Components. Histopathology, 2002. 41: 549-55

[13] Paner GP, Srigley JR, Radhakfishnan A. et al. Immunohistochemical Analysis of Mucinous Tubular and Spindle Cell Carcinoma and Papillary Renal Cell Carcinoma of the Kidney: Significant Immunophenotypic Overlap Warrants Diagnosis Caution. Am J Surg Pathol, 2006. 30: 13-9

[14] Argani P, Olgac S, Tickoo Sk et al. Xp11 Translocation Renal Cell Carcinoma in Adults: Expanded Clinical, Pathological and Genetic Spectrum. Am J Surg Pathol, 2007. 31: 1149-60.

[15] Gobbo S, Eble JN, Grignon DJ et al. Clear Cell Papillary renal Cell Carcinoma: a Distinct Histopathologic and Molecular Genetic Entity. Am J Surg Pathol, 2008. 32: 1239-45.

[16] Hussain M, Ud Din N, Azam M et Loya A. Mucinous Tubular and Spindle Cell Carcinoma of Kidney: a Clinicopathologic Study of Six Cases. Indian J Pathol Microbiol, 2012. 55(4): 439-42

[17] Wu X, Chen Y, Sha J et al. Renal Mucinous Tubular and Spindle Cell Carcinoma: a Report of 8 Cases and Review of the Literature. Diagnost Pathol, 2013. 8: 206

[18] Alexiev BA, Burke AP, Drachenber CB, Richards SM, Zou YS. Mucinous Tubular and Spindle Cell Carcinoma of the Kidney with Proeminent Papillary Component, a Non-Classic Morphologic Variant. A Histologic, Immunohistochemical, Electron Microscopic and Fluoresce In Situ Hibridization Study. Pathol – Res and Pract, 2014. 210: 454-8
Published
2015-03-22
How to Cite
OLIVEIRA, Rui Caetano et al. Mucinous tubular and spindle cell carcinoma of the kidney: case report with literature review. Diagnostic Pathology, [S.l.], mar. 2015. ISSN 2364-4893. Available at: <http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/7>. Date accessed: 26 nov. 2020. doi: https://doi.org/10.17629/www.diagnosticpathology.eu-2015-1:7.
Issue
Section
Case Report

Keywords

Spindle cell carcinoma; kidney cancer; papillary renal cell carcinoma; incidence; immunohistochemistry