Regional variation of non-Hodgkin’s Lymphoma (NHL) in Mongolia and its association with Ki-67 expression
Abstract
Background: The prevalence of non-Hodgkin’s lymphoma (NHL) varies worldwide in association with demographic and environmental factors. The analysis of these associations in Asia, Africa, and less developed countries is limited by low absolute numbers and unknown etiologic factors such as in Mongolia. The geographic variations in NHL incidence and mortality rates may induce by differences in case ascertainment and registration, or disease diagnosis and classification. The interpretation of NHL patterns and trends remains difficult. Therefore, an attempt was made to test the correlation between Ki-67 expression and clinical parameters on one hand, and geographical or ethnic differences on the other.
Research purpose: The objectives of this study are to examine the geographic distribution of non-Hodgkin's disease more in detail for high incidence Mongolian prefectures, and to evaluate the association between the distribution of NHL and Ki-67 expression.
Methods: Expression of Ki-67 was examined using an immunohistochemical technique in archival paraffin-embedded sections taken from (n=35) both National pathology center of Mongolia and Etemo clinic previously. Geo-processing was conducted with the aide of the software R Studio [under the Mapping plots] (1.0.136 version). The analyzed geographic incidence rates of NHL include locations of the central and east provinces Orkhon, Uvurhangay, Khuvsgul, Ulaanbaatar and Dornod The age-specific incidence and mortality rates were compared to those for all regions in Mongolia and those for the combined high mortality localities within the high-risk prefectures.
Results: Expression of Ki-67 protein was noted in 71.8% of the tumor cases. Average Ki-67 expression was associated with regions of high incidence.
Conclusion: We found that provinces with a high incidence and mortality from non-Hodgkin's disease were aggregated in the eastern-central parts of Mongolia, particularly in the areas along Ulaanbaatar capital city.
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